Courses / Module

Toggle Print

BIOMOLECULE PRODUCTION AND STRUCTURE DETERMINATION

Module code: CH333
Credits: 5
Semester: 2
Department: CHEMISTRY
International:

	Overview
	Biopharmaceutical chemistry and structure determination methods for biomolecules. This module examines two important areas of pharmaceutical and biomedical chemistry: (i) Biopharmaceutical chemistry. This part of the module focuses on the concepts behind the design and development of biopharmaceuticals and biologics and their roles in modern pharmaceutical chemistry and biotechnology. The course material reviews the different sources of biopharmaceuticals, and mostly focuses on the biomanufacturing process. The biochemical and molecular mechanisms of action of specific classes of biopharmaceutical drugs, such as antibodies, and the role of glycosylation of biologics is also reviewed. (ii) Structural determination methods for biomolecules: Material covered includes: Structure of biomolecules for example, biological macromolecules- proteins, nucleic acids, polysaccharides and fats and small biomolecules for example small peptides, amino acids, monosaccharides and nucleotides; chemical analysis of proteins and peptides, ESI, MALDI and Tandem Mass spectrometry, NMR spectroscopy and hardware development, FT-NMR, 2-D NMR, X-ray crystallography. Emphasis will be placed on relating each technique to determining protein structure.

Overview

Biopharmaceutical chemistry and structure determination methods for biomolecules.

This module examines two important areas of pharmaceutical and biomedical chemistry:
(i) Biopharmaceutical chemistry. This part of the module focuses on the concepts behind the design and development of biopharmaceuticals and biologics and their roles in modern pharmaceutical chemistry and biotechnology. The course material reviews the different sources of biopharmaceuticals, and mostly focuses on the biomanufacturing process. The biochemical and molecular mechanisms of action of specific classes of biopharmaceutical drugs, such as antibodies, and the role of glycosylation of biologics is also reviewed.

(ii) Structural determination methods for biomolecules: Material covered includes: Structure of biomolecules for example, biological macromolecules- proteins, nucleic acids, polysaccharides and fats and small biomolecules for example small peptides, amino acids, monosaccharides and nucleotides; chemical analysis of proteins and peptides, ESI, MALDI and Tandem Mass spectrometry, NMR spectroscopy and hardware development, FT-NMR, 2-D NMR, X-ray crystallography. Emphasis will be placed on relating each technique to determining protein structure.

	Learning Outcomes
	On successful completion of the module, students should be able to: Discuss a number of factors that are important to the techniques commonly used to obtain structural information on biomolecules. Be able to interpret the mass spectrum of a biomolecule. Be able to interpret or predict the NMR spectrum of small biomolecules. Demonstrate an understanding of what biopharmaceuticals and biologics are and their role in modern pharmaceutical chemistry. Discuss the different sources of biopharmaceuticals and the role of genomics and proteomics in biopharmaceutical chemistry. Discuss the mode of action and the uses of specific biopharmaceutical drugs.

Learning Outcomes

Teaching & Learning methods

Assessment

Module Graded (numeric value) or Ungraded (Pass/Not Passed): Graded
Continuous Assessment detail(s): Comprises of taught workshops and take home assignments. Workshops may be provided online

Assessment type	Options	Weighting	Duration
Continuous Assessment		30%
University scheduled written examination	On-campus	70%	90 minutes
Other		0%
Total		100%	90 minutes

Pass standard: 40%
Could the result of this module be capped? The module mark will be capped at 35% in cases where a student does not achieve a pass mark in the continuous assessment component of the module (i.e. continuous assessment mark of less than 40%).
The pass standard is 40%, subject to a minimum mark of 40% in the laboratory practical class component of the continuous assessment. The module mark will be capped at 35% (35% is within the compensation threshold) in cases where a student does not achieve a pass mark in the laboratory practical class component of the continuous assessment (i.e. laboratory practical class mark of less than 40%). The module mark will be capped at 35% (35% is within the compensation threshold) in cases where a student is absent from two or more laboratory practical classes. Students who obtain a capped mark because they did not achieve a pass mark in the laboratory practical class component of the continuous assessment [i.e. laboratory practical class mark of less than 40% or unsatisfactory attendance (two or more absences per module)] and who chose to sit the written exam in August cannot improve their module mark, which will remain capped at 35% (35% is within the compensation threshold). NOTE: Students should familiarise themselves with the Departmental Rules & Regulations in the Third year manual.
Penalties: There is no option to repeat the continuous assessment component of the module within the same period of study.

	Autumn Supplementals/Resits
	Are supplemental/resit registrations permitted? Yes There is an opportunity to re-sit the written examination within the same period of study, ie. Autumn. The continuous assessment mark is carried forward to the Autumn examination. Please refer to assessment rules. A student who does not pass a module may repeat the module or a suitable substitute module in a subsequent academic year. If a module has been modified or discontinued, a student may take an alternative module. University scheduled written examination (Autumn): 90 minutes, On-campus

Autumn Supplementals/Resits

	Pre-Requisites
	CH201; CH202; CH203

	Co-Requisites
	CH304C

Timetable

Search form

Courses / Module

BIOMOLECULE PRODUCTION AND STRUCTURE DETERMINATION

Semester 1

Semester 2