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TUMOUR BIOLOGY

Module code: BI407
Credits: 5
Semester: 1
Quota: 150
Department: BIOLOGY
International:
Coordinator: Dr Marion Butler (BIOLOGY)

	Overview
	The course is lecture based with prescribed additional reading and self directed private study. The course examines the question “What is Cancer?� To answer this, the following topics are explored: Control of the Cell division cycle; Cyclins and cyclin dependent kinases; Oncogenes, Tumour suppressor genes; Familial cancers; a detailed study of the role of the Rb gene; P53 as the guardian of the genome; Cell death Mechanisms; Intrinsic and Extrinsic pathways of apoptosis; detailed understanding of the anti-tumour immune response; understanding failures in the anti-tumour immune response; immunotherapies with a focus on immune checkpoint inhibitors; Breast cancer; Ovarian cancer; tumour progression; Angiogenesis, how diagnosis is made; the major therapeutic interventions (existing therapies and new therapies).

Overview

The course is lecture based with prescribed additional reading and self directed private study. The course examines the question “What is Cancer?� To answer this, the following topics are explored: Control of the Cell division cycle; Cyclins and cyclin dependent kinases; Oncogenes, Tumour suppressor genes; Familial cancers; a detailed study of the role of the Rb gene; P53 as the guardian of the genome; Cell death Mechanisms; Intrinsic and Extrinsic pathways of apoptosis; detailed understanding of the anti-tumour immune response; understanding failures in the anti-tumour immune response; immunotherapies with a focus on immune checkpoint inhibitors; Breast cancer; Ovarian cancer; tumour progression; Angiogenesis, how diagnosis is made; the major therapeutic interventions (existing therapies and new therapies).

	Learning Outcomes
	On successful completion of the module, students should be able to: Identify the fundamental biological processes that contribute to cancer. Describe the multifactorial relationship between molecular, cellular and environmental processes, with regard to carcinogenesis. Evaluate various types of scientific information including recent primary research articles with regard to cancer biology, diagnosis and treatment. Communicate effectively in written and oral forms. Construct simple hypotheses consistent with current scientific knowledge as a basis for future research in cancer.

Learning Outcomes

Teaching & Learning methods

Assessment

	Autumn Supplementals/Resits
	Are supplemental/resit registrations permitted? Yes University scheduled written examination (Autumn): 120 minutes, On-campus

	Pre-Requisites
	BI210 and BI304, or equivalent.

Timetable

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TUMOUR BIOLOGY

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