Courses / Module

Toggle Print


Module code: CH427
Credits: 5
Semester: 2
Department: CHEMISTRY
International: Yes
Overview Overview

Bio-Inorganic Chemistry. Entatic state and HSAB theory. Common ligand types found in biological systems. Structure of the 20 aminoacids. Potassium ion channels, sodium/potassium pump. Oxygen transport. Molecular orbital of O2 molecules, ground state and excited state of O2. Oxygen and reactive oxygen species (ROS). Mechanism of action of Superoxodismutase, Catalase and Cytocrome C oxidase enzymes. Electron transfer (cytochromes, iron-sulphur clusters, copper enzymes). Acid-base catalysis (zinc enzymes). Zinc fingers proteins. Metal-Based Drugs: Historic perspective of the uses of metal ions in medicine. Details of selected metallo-therapeutics such as platinum and gold. f-block chemistry with application in medicinal chemistry. Metal-based therapeutic radiopharmaceuticals and medical imaging agents. Magnetic resonance imaging - theory and f-block contrast agents.

Open Learning Outcomes
Open Teaching & Learning methods
Open Assessment
Open Repeat options
Open Pre-Requisites
Open Timetable
Copyright © 2017 Maynooth University
Maynooth, Co. Kildare, Ireland
Tel: +353(1) 7086000
Powered by MDAL Framework © 2019
V5.2.0 - Powered by MDAL Framework © 2019